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Wednesday, January 07, 2009

Cushing’s disease presents with

Question 86
Cushing’s disease presents with
a.       Increased ACTH, Increased Cortisol
b.      Decreased ACTH and Decreased Cortisol
c.       Increased ACTH and Decreased Cortisol
d.      Increased Catecholamines
Answer
a. Increased ACTH and Increased Cortisol
Reference
Harrison 16th Edition Page 2135
QTDF
Harrison
Quality
Reader
Status
New
Discussion
Cushing's syndrome (also called hypercortisolism or hyperadrenocorticism) is an endocrine disorder caused by high levels of cortisol in the blood from a variety of causes, including primary pituitary adenoma (known as Cushing's disease), primary adrenal hyperplasia or neoplasia, ectopic ACTH production (e.g., from a small cell lung cancer), and iatrogenic (steroid use).
Explanation
Self Explanatory
Comments
Cushing's disease was described by American physician, surgeon and endocrinologist Harvey Cushing (1869-1939) and reported by him in 1932.
Tips
Question about the earliest manifestation of Cushings was asked in 2004

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