TNPG 2006 PHARMACOLOGY

PHARMACOLOGY

1) Drug induced parkinsonism is treated by

a. Carbidopa

b. Bromocriptine

c. Benzhexol

d. Selegiline

Answer : C) Benzhexol

Reference: KDTripathi 5^th Edition Page 388

2) Drug with high degree of Photosensitivity is

a. Tetracycline

b. Doxycycline

c. Minocycline

d. Methacycline

Answer : b) Doxycline

Reference: KDTripathi 5^th Edition Page 672

3) Minoxidil

a. Topical Application is used in Alopecia

b. Acts on Arteriolar smooth muscles causing relaxation

c. Leads to Sodium Retention

d. All of the above

Answer : D) All of the above

Reference: KDTripathi 5^th Edition Page 513

4) Thrombolytic therapy with Streptokinase is Contraindicated in all of the following except

a. Supra ventricular Tachycardia

b. Recent Trauma

c. Recent Cerebral Bleeding

d. Recent Surgery

Answer : a) Supra ventricular Tachycardia

Reference: KDTripathi 5^th Edition Page 571

5) Carbenazolone Sodium

a. Promotes Ulcer Healing

b. Slows down Prostaglandin degradation

c. Derived from Glycyrrhetinic Acid

d. All of the above

Answer : d) All of the above

Reference: KDTripathi 5^th Edition Page 597

6) Treatment of Lepra Reaction includes

a. Thalidomide

b. Steroids

c. Clofazamine

d. All of the above

Answer : D) All of the above

Reference: KDTripathi 5^th Edition Page 714

7) Drug used for treatment of Methicillin Resistant Staphylococcus Aureus

a. Teicoplanin

b. Vancomycin

c. Both

d. None

Answer : C) Both

Reference: KDTripathi 5^th Edition Page 691

8) Which is obtained from a natural source Naturallly acquiring product –

a. Physostigmine

b. Pilocarpine

c. Heparin

d. All of the above

Answer : D) All of the above

Reference: KDTripathi 5^th Edition Page 81, 561

Physostigmine occurs naturally in Calabar or Ordeal bean, Ripe seed of Physostigm venenosum, Heparin in Liver and granulocytes of mast cells, Sulfonamides in Azo dyes, Liq.paraffin in Hydrocarbons.

9) Mechanism of action of Aspirin is inhibition of

a. Thromboxane A2 Synthesis

b. Phosphodiesterase

c. HMG- CoA Reductase

d. Pancreatic Lipase

Answer : A) Thromboxane A2 Synthesis

Reference: Harper 27^th Edition Page 204

10) Folic acid

a. Is also called as Pteroyl Glutamic Acid

b. Is useful in Carriage of one Carbon atom moiety

c. Tetra hydro folate is the active form

d. All of the above

Answer : d) All of the above

Reference: Chaterjee 6^th Edition Page 174

11) Gene therapy is used for all the following except

a. Gene Addition

b. Gene Correction

c. Modify Vascular Biology

d. None

Answer : d) None

Reference: Harrison 16^th Edition Page 392

12) Local Anaesthetics act by

a. Blocking Na and Preventing depolarisation

b. Inhibiting Aldose reductase

c. Increasing degradation of Adrenaline

d. None of the above

Answer : a) Blocking Na and Preventing depolarisation

Reference: KDTripathi 5^th Edition Page 321

TNPG 2005 Pharmacology

PHARMACOLOGY

1) Actions of opiates in man are all except

a. Constipation

b. Mydriasios

c. Vomiting

d. Analgesia

Answer : b) Mydriasis

Reference: Tripathi 5^th Edition Page 421

2) Drug of choice for Prophylaxis of meningococcal meningitis is

a. Rifampicin

b. Penicillin

c. Erythromycin

d. Septran

Answer : a) Rifampicin

Reference: Tripathi 5^th Edition Page 701

3) Gray Baby syndrome is caused by

a. Chloramphenicol

b. Cycloserin

c. Kanamycin

d. Thioacetazone

Answer : a) Chloramphenicol

Reference: Tripathi 5^th Edition Page 675

4) Which of the following is a Cholestatic drug

a. Erythromycin

b. Phenothiazines

c. Oral Contraceptives

d. All of the above

Answer : d) All of the above

Reference: Harrison 15^th Edition Page 434

5) Ceftriaxone is

a. II Generation short acting

b. III generation long acting

c. active against beta lactamase

d. IV generation used orally

Answer : b) III Generation Long Acting

Reference: Tripathi 5^th Edition Page 665

6) Treatment of bacterial vaginosis. Drug of choice is

a. Ampicillin

b. Metronidazole

c. Ciprofloxacin

d. Fluconazole

Answer : Metronidazole

Reference: Dutta Gynaec 2^nd Edition Page 151

7) Bioavailability is defined as

a. The percentage of drug that is detected in the systemic circulation after its administration

b. The volume of plasma completely cleared of a specific compound per unit time and measured as a test of kidney function.

c. Both

d. None

Answer : The percentage of drug that is detected in the systemic circulation after its administration

Reference: Tripathi 5^th Edition Page 15

8) Which of the following is a Prodrug

a. Enalapril

b. Dopamine

c. AMpicillin

d. Prednisolone

Answer d) Enalapril:

Reference: Tripathi 5^th Edition Page 20

9) Cyclosporine side effect all except

a. Post-transplant lymphoproliferative disorders (PTLDs),

b. nephrotoxicity

c. tremors

d. Hypotension

Answer : d) Hypotension

Reference: Tripathi 5^th Edition Page 788

10) True about Sumatriptan

a. Antagonist of Serotonin

b. Interacts with alpha and beta adrenergic receptors

c. Has antimigranic activity

d. Can be used in a patient with Ischemic Heart disease

Answer : Has antimigranic activity

Reference: Tripathi 5^th Edition Page 153

11) Anticholine esterase with effect on CNS

a. Physostigmine

b. Neostigmine

c. Dacrine

d. Edrophonium

Answer :

Reference: Tripathi 5^th Edition Page

12) DOC for Herpes

a. Acyclovir

b. Zidovudine

c. Indinavir

d. Ribavarin

Answer : a) Acyclovir

Reference: Tripathi 5^th Edition Page 726