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Wednesday, January 09, 2008

tRNA has the highest percentage of modified base

044. Which type of RNA has the highest percentage of modified base:

1. mRNA

2. tRNA

3. rRNA

4. snRNA


3. rRNA


Harper 26th Edition Page 356

Chaterjee 6th Edition Page 222 Table 16.3





Most books


Ä The tRNAs contain many modifications of the standard bases A,U,G and C, including methyaltion, reduction, deamination and rearranged glycosidic bonds.

Ä Further modification of the tRNA molecules includes nucleotide alkylations and the attachment of the characteristic CpCpAOH terminal at the 3’ end of the molecule by the enzyme nucleotidyl transferase


Self Explanatory


Though it is given in books that tRNA has more number of modified bases than mRNA or rRNA, we have no specific information about bases in the snRNA


Consider this answer with the proverbial “pinch of salt”

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