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MCQ stands for Multiple Choice Questions sometimes called as Objective type questions. Here we discuss the Old Question Papers, High Yield Points and Strategies with respect to the Indian Medical Post Graduate PG Entrance Exams like AIIMS,AIPG, JIPMER, CMC Vellore, PGI Chandigarh, UPSC, TNPSC, State PG Exams like Tamil Nadu PG (TN PG), Delhi PG, UPPG, Tamilnadu PG (TNPG), Karnataka PG, MAHE, COMED-K etc.

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Monday, December 15, 2008

Vitamin K is required for carboxylation of clotting factors..

Question 24
Which Vitamin is required for carboxylation of clotting factors..
a.       Vitamin A
b.      Vitamin D
c.       Vitamin E
d.      Vitamin K

Answer

d) Vitamin K

Reference

Harper 27th Edition Page : 495
QTDF
All Book

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Discussion

Vitamin K (K from "Koagulation" in German) denotes a group of lipophilic (fat-soluble), and hydrophobic, vitamins that are needed for the posttranslational modification of certain proteins, mostly required for blood coagulation. Chemically they are 2-methyl-1,4-naphthoquinone derivatives.
Vitamin K2 (menaquinone, menatetrenone) is normally produced by bacteria in the intestines, and dietary deficiency is extremely rare unless the intestines are heavily damaged or are unable to absorb the molecule

Explanation

Self Explanatory
Vitamin K is required for Synthesis of Blood Clotting Proteins. Vitamin K is the Co Enzyme for carboxylation of Glutamate in Post Synthetic Modification of Calcium Binding Proteins.

Comments

Ä     Vitamin K is also important in synthesis of Bone Calcium Binding Proteins
Ä     The recommended Daily Allowance is 120 microgram

Tips

There is an unrelated drug sometimes referred to in slang as vitamin K. It is Ketamine

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