MCQsOnline - Online Collection of MCQs of Medical PG Entrance Exams.

MCQ stands for Multiple Choice Questions sometimes called as Objective type questions. Here we discuss the Old Question Papers, High Yield Points and Strategies with respect to the Indian Medical Post Graduate PG Entrance Exams like AIIMS,AIPG, JIPMER, CMC Vellore, PGI Chandigarh, UPSC, TNPSC, State PG Exams like Tamil Nadu PG (TN PG), Delhi PG, UPPG, Tamilnadu PG (TNPG), Karnataka PG, MAHE, COMED-K etc.

Target PG

PG Preparation

Related Portals

Search This Site

If you cannot locate what you want to find, please search using the box given below

Tuesday, March 11, 2008

Slit lamp examination of eye

067. A patient had seven irregular hyperpigmented macules on the trunk and multiple small hyperpigmented macules in the axillae and groins since early childhood. There were no other skin lesions. Which is the most likely investigation to support the diagnosis?

1. Slit lamp examination of eye

2. Measurement of intraocular tension

3. Examination of fundus

4. Retinal artery angiography


1. Slit lamp examination of eye


Harrison 16th Edition Page 2457






It is easy to arrive at an diagnosis. Axillary hyperpigmentations point to Neurofibromatosis. To confirm the diagnosis, we have to look for the Lisch nodules.


1. Slit lamp examination of eye is done to diagnose Lisch nodules of Iris

2. Measurement of intraocular tension is also needed in Neurofibromatosis to rule out Congenital Glaucoma (often associated with the disease) but is not the most likely investigation to support the diagnosis

3. Examination of fundus is also done, but not for supporting the diagnosis

4. Retinal artery angiography will not help in supporting the diagnosis


Ocular manifestations of neurofibromatosis include

  1. Plexiform tumours of lids with Ptosis
  2. Thickened corneal nerves
  3. Pulsating proptosis (due to transmitted cerebral pulsations through the defects in the orbital walls)
  4. Glioma of optic nerve
  5. Congenital Glaucoma


Mutation of the NF1 gene on chromosome 17 causes von Recklinghausen's disease. The NF1 gene is a tumor suppressor gene; it encodes a protein, neurofibromin, which modulates signal transduction through the ras GTPase pathway. Patients with NF1 are at increased risk of developing nervous system neoplasms, including plexiform neurofibromas, optic gliomas, ependymomas, meningiomas, astrocytomas, and pheochromocytomas. Neurofibromas may undergo secondary malignant degeneration and become sarcomas.

No comments:

Post a Comment