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Monday, December 15, 2008

ATP does not form in.. HMP Pathway

Question 27
ATP does not form in..
a.       Glycolysis
b.      TCA Cycle
c.       Fatty Acid Oxidation
d.      HMP Pathway
Answer
d. HMP Pathway
Reference :
Harper 27th edition Page 177
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Discussion
The pentose phosphate pathway is an alternative route for the metabolism of glucose. It does not lead to formation of ATP but has two major functions
1.      The formation of NADPH for synthesis of fatty acids
2.      The formation of Ribose for nucleotide and nucleic acid formation
Explanation
Ä     Glycolysis leads to a net gain of 8 ATP per molecule of Glucose in aerobic conditions
Ä     TCA Cycle gives a net gain for 30 molecules per glucose molecule in aerobic conditions
Ä     Oxidation of fatty acids give ATP (the exact number depends on the fatty acid. Palmitic acid, for example, gives a net gain of 129 ATP. [(7cycles x 5per cycle) +  (8 Acetly CoA x12 per Acetyl CoA) – 2]
Comments
Pentose Phosphate Pathway is also called as
1.      Hexose Monophosphate pathway or Shunt
2.      Pentose Cycle
3.      Phosphogluconate pathway
4.      Warburg-Dickens0 Lipman Pathway
Tips
This pathway occurs in specialized tissues to serve specialized functions
1.      Liver
2.      Adipose Tissue
3.      RBC
4.      Testes
5.      Ovary
6.      Adrenal Cortex
7.      Lactating Mammary Glands

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