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Wednesday, January 09, 2008

amino acids are converted to succinyl – CoA, except Histidine

039. All of the following amino acids are converted to succinyl – CoA, except:

1. Methionine

2. Isoleucine

3. Valine

4. Histidine


4. Histidine


Harper 26th Edition Pages 249, 262

Lippincott 3rd Edition Page 261 to 263

Chaterjee 6th Edition Page 457





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Amino acids that forms Succinyl CoA are

1. Methionine through Propionyl CoA

2. Valine through L-Methyl Malonyl CoA

3. Isoleucine through Propionyl CoA

4. Threonine through Propionyl CoA (Threonine undergoes non oxidative deamination to become Propionyl CoA)

Propionyl CoA is converted to Succinyl CoA. Other sources of Propionyl CoA are

1. Beta oxidation of odd chain fatty acids

2. Oxidative decarboxylation of alpha keto glutarate

3. Activation of Succinic Acid


Histidine metabolism yield

1. Urocanic acid

2. 4-imidazolone-5-propionate

3. Formiminoglutamic acid (Fliglu)

4. Glutamate


Histidine also forms

1. Ergothioneine

2. Carnosine

3. Anserine


Carnosine is a dipeptide of histidine with beta-alanine (b-alanyl histidine). It is present in skeletal muscle

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